TSEN2

Across TCGA patient cohorts, TSEN2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSEN2-associated genes across cancer lineages are Annexin_VII, ASNS, and 14-3-3_beta. Each is linked with TSEN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSEN2-to-partner and partner-to-TSEN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by TSEN2-low versus TSEN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSEN2→partner) and Y-score (partner→TSEN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.148	-2.087	.005	.005	3	2
UCEC	ASNS →	+0.490	+2.115	<.001	.017	3	2
UCEC	14-3-3_beta →	-0.101	-3.295	.009	.009	3	1
UCEC	EGFR_pY1068 →	-0.278	-2.087	.003	.005	3	1
UCEC	eIF4E →	+0.189	+3.183	.019	.009	3	1
UCEC	A-Raf_pS299 →	-0.115	-2.000	.011	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Annexin_VII by TSEN2 expression — UCEC

Explore this box plot interactively →