TSEN2

Across TCGA cell cohorts, TSEN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,185 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TSEN2-associated GO terms across cancer lineages are tRNA-type intron splice site recognition and cleavage, tRNA metabolic process, and tRNA 3'-terminal CCA addition. Each is linked with TSEN2 in more than 19 cancer types. Because this analysis shows association rather than direction, both TSEN2-to-partner and partner-to-TSEN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA-type intron splice site recognition and cleavage grouped by TSEN2-low versus TSEN2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSEN2→partner) and Y-score (partner→TSEN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	tRNA-type intron splice site recognition and cleavage →	+0.155	+1.137	<.001	.001	3	20
LUNG_SCLC	tRNA metabolic process →	+0.058	+0.738	.001	.001	3	14
KIDNEY	tRNA 3'-terminal CCA addition →	+0.126	+0.735	.001	.005	3	14
LUNG_SCLC	Mitochondrial tRNA 3'-end processing →	+0.129	+0.796	<.001	<.001	3	14
KIDNEY	tRNA processing →	+0.054	+1.093	<.001	<.001	3	13
KIDNEY	RNA 5'-end processing →	+0.068	+0.887	<.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,185 associations by consensus.

tRNA-type intron splice site recognition and cleavage by TSEN2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →