TSEN15P1

Across TCGA pan-cancer cohorts, TSEN15P1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TSEN15P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TSEN15P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSEN15P1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where TSEN15P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSEN15P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.262	<.001	8	view →
KIRC	Male	II,III,IV	−0.127	<.001	8	view →
LUSC	All	All	+0.144	.003	4	view →
BRCA	Female	All	+0.108	<.001	4	view →
KICH	All	II,III,IV	−0.205	.012	3	view →
UCEC	All	All	+0.194	.036	2	view →
COAD	All	II,III,IV	+0.142	.014	2	view →
CHOL	All	All	+0.161	.030	1	view →
LUAD	All	All	+0.129	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TSEN15P1–HNSC

Open the HNSC breakdown →