TSC22D4

Across TCGA patient cohorts, TSC22D4 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSC22D4-associated genes across cancer lineages are EGFR_pY1068, ERK2, and PCNA. Each is linked with TSC22D4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSC22D4-to-partner and partner-to-TSC22D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TSC22D4-low versus TSC22D4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC22D4→partner) and Y-score (partner→TSC22D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.303	-2.584	.009	.011	3	1
UCEC	ERK2 →	+0.238	+3.169	.008	.018	3	1
UCEC	PCNA →	+0.240	+2.999	.017	.035	3	1
UCEC	PI3K-p85 →	+0.376	+3.469	<.001	.002	3	1
UCEC	Annexin-1 →	+0.624	+3.189	.010	.010	3	1
UCEC	STAT3_pY705 →	-0.367	-3.169	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by TSC22D4 expression — UCEC

Explore this box plot interactively →