TSC22D4

Across TCGA cell cohorts, TSC22D4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,411 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TSC22D4-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Negative regulation of cytoplasmic pattern recognition receptor signaling pathway, and Negative regulation of respiratory burst involved in inflammatory response. Each is linked with TSC22D4 in more than 14 cancer types. Because this analysis shows association rather than direction, both TSC22D4-to-partner and partner-to-TSC22D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by TSC22D4-low versus TSC22D4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC22D4→partner) and Y-score (partner→TSC22D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Pre-mRNA catabolic process →	+0.217	+0.750	<.001	<.001	3	15
BONE	Negative regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.072	+0.850	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of respiratory burst involved in inflammatory response →	+0.080	+0.966	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of respiratory burst →	+0.080	+0.966	<.001	.001	3	11
KIDNEY	Maintenance of unfolded protein →	+0.168	+0.887	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Endocytic recycling →	+0.067	+0.883	.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,411 associations by consensus.

Pre-mRNA catabolic process by TSC22D4 expression — BONE

Explore this box plot interactively →