TSC22D4

Across TCGA cell cohorts, TSC22D4 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSC22D4-associated genes across cancer lineages are USP17L3, MAGEB4, and GFRA4. Each is linked with TSC22D4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSC22D4-to-partner and partner-to-TSC22D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L3 grouped by TSC22D4-low versus TSC22D4-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC22D4→partner) and Y-score (partner→TSC22D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	USP17L3 →	+0.016	+5.000	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	GFRA4 →	+0.019	+3.345	.001	.007	3	1
LARGE_INTESTINE	OR52H1 →	+0.025	+3.347	<.001	.005	3	1
LARGE_INTESTINE	PSMB11 →	+0.021	+3.878	.004	.003	3	1
LARGE_INTESTINE	SPEM3 →	+0.013	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

USP17L3 by TSC22D4 expression — PANCREAS

Explore this box plot interactively →