TSC22D3

Across TCGA patient cohorts, TSC22D3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSC22D3-associated genes across cancer lineages are ATM, eIF4G, and A-Raf_pS299. Each is linked with TSC22D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSC22D3-to-partner and partner-to-TSC22D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TSC22D3-low versus TSC22D3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC22D3→partner) and Y-score (partner→TSC22D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.760	-2.807	<.001	.003	3	2
UCEC	eIF4G →	+0.289	+2.321	.024	.034	3	1
UCEC	A-Raf_pS299 →	-0.131	-3.169	.007	.019	3	1
UCEC	ERK2 →	+0.217	+3.321	.006	.009	3	1
UCEC	FoxM1 →	+0.216	+2.321	.043	.006	3	1
UCEC	GATA6 →	-0.243	-3.570	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ATM by TSC22D3 expression — UCEC

Explore this box plot interactively →