TSC22D3

Across TCGA cell cohorts, TSC22D3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TSC22D3-associated genes across cancer lineages are GAGE12J, ODF1, and SPINK9. Each is linked with TSC22D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSC22D3-to-partner and partner-to-TSC22D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12J grouped by TSC22D3-low versus TSC22D3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC22D3→partner) and Y-score (partner→TSC22D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
SKIN	ODF1 →	+0.026	+6.022	<.001	.001	3	1
SKIN	SPINK9 →	+0.058	+5.415	<.001	.004	3	1
SKIN	OOSP4B →	+0.075	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GAGE12J by TSC22D3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →