Across TCGA cell cohorts, TSC22D2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSC22D2-associated genes across cancer lineages are BTNL2, OR2B3, and CELA2B. Each is linked with TSC22D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSC22D2-to-partner and partner-to-TSC22D2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC22D2→partner) and Y-score (partner→TSC22D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR2B3 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CELA2B →	+0.084	+4.273	<.001	.006	3	1
LARGE_INTESTINE	POTEB2 →	+0.009	+4.415	<.001	.007	3	1
CNS	PRAMEF26 →	+0.270	+5.754	.005	.002	3	1
LUNG_NSCLC_LUAD	GDF3 →	+0.022	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

TSC22D2 survival (RNA) · tumor vs normal (RNA) · all TSC22D2 data types