TSC2

Across TCGA pan-cancer cohorts, TSC2 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TSC2 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TSC2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSC2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, LUAD, and UCEC are the cancer types where TSC2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.230	0.533	.009	12	view →
LUAD	OS	Median	II,III,IV	0.326	0.753	.013	12	view →
UCEC	DFS	Median	All	0.955	0.609	.005	12	view →
KIRC	OS	Median	All	0.249	0.810	.011	6	view →
BLCA	DFS	Median	All	0.402	0.633	.026	6	view →
SCLC	DFS	Median	All	0.192	0.793	.017	6	view →
LIHC	DFS	Median	All	0.122	0.530	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TSC2–ESCA (DFS)

Open the ESCA breakdown →