TSC1

Across TCGA pan-cancer cohorts, TSC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TSC1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TSC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TSC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where TSC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	1.000	0.781	.002	42	view →
LUAD	DFS	Tertile	III,IV	1.000	0.498	.001	22	view →
HNSC	DFS	Median	III,IV	1.000	0.903	.004	18	view →
GBM	DFS	Quartile	All	0.454	0.227	.028	3	view →
PDAC	OS	Median	IV	0.937	0.395	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TSC1–CCRCC (OS)

Open the CCRCC breakdown →