TSC1

Across TCGA patient cohorts, TSC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,411 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible TSC1-associated proteins across cancer lineages are PTPA, BRD3, and PDIA6. Each is linked with TSC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both TSC1-to-partner and partner-to-TSC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSC1 versus PTPA in OV, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC1→partner) and Y-score (partner→TSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PTPA →	+0.481	+0.875	.001	<.001	3	7
GBM	BRD3 →	+0.299	+0.303	<.001	<.001	3	7
BRCA	PDIA6 →	-0.382	-0.635	<.001	<.001	3	6
BRCA	SET →	+0.309	+0.494	.002	<.001	3	6
BRCA	C9orf64 →	+0.403	+0.459	<.001	.002	3	6
GBM	CIZ1 →	+0.363	+0.437	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,411 associations by consensus.

TSC1 vs PTPA — OV

Explore this scatter interactively →