TSC1

Across TCGA patient cohorts, TSC1 mutation is significantly associated with the RNA expression of many other genes, with 4,458 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSC1-associated genes across cancer lineages are C6orf99, SMARCE1P2, and SBF2-AS1. Each is linked with TSC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSC1-to-partner and partner-to-TSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf99 grouped by TSC1-low versus TSC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC1→partner) and Y-score (partner→TSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	C6orf99 →	+0.524	+3.258	<.001	.008	3	3
UCEC	SMARCE1P2 →	+0.119	+1.617	<.001	<.001	3	3
UCEC	SBF2-AS1 →	+0.389	+1.959	<.001	<.001	3	3
UCEC	UGDH →	+0.498	+1.455	.002	.005	3	3
UCEC	GOT1 →	+0.328	+1.649	.001	<.001	3	3
UCEC	EIF5A →	+0.244	+2.385	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,458 associations by consensus.

C6orf99 by TSC1 expression — SKCM

Explore this box plot interactively →