TSC1

Across TCGA patient cohorts, TSC1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSC1-associated genes across cancer lineages are Bim, MSH2, and Tuberin. Each is linked with TSC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSC1-to-partner and partner-to-TSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bim grouped by TSC1-low versus TSC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC1→partner) and Y-score (partner→TSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Bim →	-0.313	-3.000	.040	.036	3	3
BLCA	MSH2 →	-0.176	-2.321	.021	.032	3	2
BLCA	Tuberin →	-0.363	-1.999	.001	.008	3	2
UCEC	eEF2 →	+0.315	+2.807	.003	.002	3	2
UCEC	eIF4E →	+0.168	+2.392	.008	<.001	3	2
UCEC	FoxM1 →	+0.175	+1.530	.025	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Bim by TSC1 expression — SKCM

Explore this box plot interactively →