TSACC

Across TCGA patient cohorts, TSACC mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSACC-associated genes across cancer lineages are RNU1-80P, RN7SKP265, and MIR3119-2. Each is linked with TSACC in more than 2 cancer types. Because this analysis shows association rather than direction, both TSACC-to-partner and partner-to-TSACC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-80P grouped by TSACC-low versus TSACC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSACC→partner) and Y-score (partner→TSACC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-80P →	+0.368	+5.038	<.001	<.001	3	3
UCEC	RN7SKP265 →	+0.166	+4.727	<.001	.003	3	2
SKCM	MIR3119-2 →	+0.368	+7.816	<.001	.008	3	2
BLCA	PSMB7P1 →	+0.104	+7.640	<.001	.009	3	1
SKCM	H2AB3 →	+0.109	+7.816	<.001	.008	3	1
SKCM	BTG3P1 →	+0.089	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

RNU1-80P by TSACC expression — UCEC

Explore this box plot interactively →