Across TCGA pan-cancer cohorts, TRRAP mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TRRAP data layer compared with 24 for mass-spec protein and 14 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TRRAP mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TRRAP expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where TRRAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.959	0.618	.002	13	view →
CCRCC	OS	Median	All	0.783	1.000	.030	2	view →
PDAC	OS	Tertile	All	0.447	0.598	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TRRAP tumor-vs-normal RNA expression · all TRRAP data types