Across TCGA patient cohorts, TRRAP mutation is significantly associated with the RNA expression of many other genes, with 9,653 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRRAP-associated genes across cancer lineages are CDC45, CENPU, and CCNB2. Each is linked with TRRAP in more than 6 cancer types. Because this analysis shows association rather than direction, both TRRAP-to-partner and partner-to-TRRAP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRRAP→partner) and Y-score (partner→TRRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDC45 →	+0.419	+1.006	<.001	.002	3	7
STAD	CENPU →	+0.529	+2.597	.002	<.001	3	6
STAD	CCNB2 →	+0.567	+2.906	.001	.001	3	6
STAD	THOP1 →	+0.397	+2.584	.001	<.001	3	6
UCEC	CDKN3 →	+0.408	+1.540	<.001	<.001	3	6
STAD	PTTG1 →	+0.550	+2.700	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,653 associations by consensus.

Exploration

TRRAP survival (RNA) · tumor vs normal (RNA) · all TRRAP data types