Across TCGA patient cohorts, TRRAP mutation is significantly associated with the total protein of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRRAP-associated genes across cancer lineages are TFRC, Bcl-2, and Cyclin-B1. Each is linked with TRRAP in more than 5 cancer types. Because this analysis shows association rather than direction, both TRRAP-to-partner and partner-to-TRRAP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRRAP→partner) and Y-score (partner→TRRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TFRC →	+0.600	+3.700	.003	.001	3	6
LUAD	Bcl-2 →	-0.335	-3.584	.004	.002	3	5
UCEC	Cyclin-B1 →	+0.406	+1.263	<.001	.001	3	5
OV	Cyclin-E1 →	+0.724	+3.000	.003	.034	3	5
COAD	ATM →	-0.474	-2.169	<.001	.002	3	5
SKCM	PCNA →	+0.204	+1.637	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

Exploration

TRRAP survival (RNA) · tumor vs normal (RNA) · all TRRAP data types