TRPV6

Across TCGA patient cohorts, TRPV6 mutation is significantly associated with the RNA expression of many other genes, with 4,671 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPV6-associated genes across cancer lineages are PRC1, SNRPD3, and VRK1. Each is linked with TRPV6 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRPV6-to-partner and partner-to-TRPV6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRC1 grouped by TRPV6-low versus TRPV6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPV6→partner) and Y-score (partner→TRPV6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRC1 →	+1.004	+3.700	<.001	.001	3	4
SKCM	SNRPD3 →	+0.297	+2.138	.001	.002	3	4
LUAD	VRK1 →	+0.440	+3.735	.006	<.001	3	4
LUAD	OIP5 →	+0.942	+3.735	<.001	<.001	3	4
LUAD	KNSTRN →	+0.545	+3.333	.002	.005	3	4
LUAD	NUSAP1 →	+0.885	+2.502	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,671 associations by consensus.

PRC1 by TRPV6 expression — LUAD

Explore this box plot interactively →