TRPV6

Across TCGA cell cohorts, TRPV6 mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPV6-associated genes across cancer lineages are ZNF683, OR2B3, and SLC10A2. Each is linked with TRPV6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPV6-to-partner and partner-to-TRPV6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF683 grouped by TRPV6-low versus TRPV6-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPV6→partner) and Y-score (partner→TRPV6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF683 →	+0.033	+3.321	<.001	.006	3	2
LARGE_INTESTINE	OR2B3 →	+0.010	+3.192	<.001	.002	3	2
OESOPHAGUS	SLC10A2 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	ZNF99 →	+0.023	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Leukemia	TRIM49 →	+0.002	+4.247	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

ZNF683 by TRPV6 expression — CNS

Explore this box plot interactively →