TRPV5

Across TCGA pan-cancer cohorts, TRPV5 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TRPV5 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TRPV5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TRPV5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC and HNSC are the cancer types where TRPV5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.936	0.486	.013	5	view →
HNSC	DFS	Median	IV	1.000	0.910	.041	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TRPV5–PDAC (OS)

Open the PDAC breakdown →