TRPV5

Across TCGA patient cohorts, TRPV5 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPV5-associated genes across cancer lineages are ATM, C-Raf, and MSH2. Each is linked with TRPV5 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRPV5-to-partner and partner-to-TRPV5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TRPV5-low versus TRPV5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPV5→partner) and Y-score (partner→TRPV5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.352	-2.308	.016	.033	3	4
UCEC	C-Raf →	+0.102	+1.807	.028	.025	3	3
UCEC	MSH2 →	-0.206	-2.089	.005	.016	3	2
UCEC	NF-kB-p65_pS536 →	-0.304	-1.797	.039	.025	3	2
UCEC	PDCD4 →	-0.524	-1.459	<.001	.012	3	2
UCEC	Annexin-1 →	+0.432	+1.716	.011	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

ATM by TRPV5 expression — UCEC

Explore this box plot interactively →