Across TCGA patient cohorts, TRPV1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPV1-associated genes across cancer lineages are ATM, AR, and Caspase-7-cleavedD198. Each is linked with TRPV1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPV1-to-partner and partner-to-TRPV1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPV1→partner) and Y-score (partner→TRPV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.389	-2.102	.011	.016	3	3
COAD	AR →	+0.216	+2.178	.012	.035	3	2
COAD	Caspase-7-cleavedD198 →	+1.520	+3.186	<.001	.009	3	2
COAD	C-Raf →	+0.184	+2.178	.007	.035	3	2
UCEC	EGFR_pY1068 →	-0.189	-1.247	.026	.045	3	2
SKCM	Annexin-1 →	+0.776	+3.169	.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

TRPV1 survival (RNA) · tumor vs normal (RNA) · all TRPV1 data types