Across TCGA cell cohorts, TRPV1 mutation is significantly associated with the mutation status of many other genes, with 2,834 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPV1-associated genes across cancer lineages are GCN1, PDZD2, and KALRN. Each is linked with TRPV1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPV1-to-partner and partner-to-TRPV1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPV1→partner) and Y-score (partner→TRPV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GCN1 →	+3.440	+5.016	<.001	<.001	1	5
SOFT_TISSUE	PDZD2 →	+3.329	+4.562	.003	.003	1	5
BLOOD_Lymphoma	KALRN →	+2.832	+3.601	.008	.008	1	5
UPPER_AERODIGESTIVE_TRACT	LZTR1 →	+5.392	+5.392	.004	.004	1	4
SKIN	BRINP2 →	+2.352	+4.062	.004	.004	1	4
SKIN	PRKDC →	+2.593	+4.282	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,834 associations by consensus.

Exploration

TRPV1 survival (RNA) · tumor vs normal (RNA) · all TRPV1 data types