TRPS1

Across TCGA pan-cancer cohorts, TRPS1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated TRPS1 data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TRPS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRPS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and READ show a favorable association.

LIHC, UCEC, and OV are the cancer types where TRPS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.304	0.791	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.945	0.300	.004	28	view →
OV	DFS	Median	II,III,IV	0.189	0.542	.005	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
THYM	OS	Median	All	0.352	0.884	<.001	8	view →
LUAD	OS	Median	All	0.102	0.383	.011	8	view →
GBM	DFS	Median	All	0.043	0.243	.003	6	view →
PRAD	DFS	Median	All	0.617	0.886	.015	6	view →
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	3	view →
READ	DFS	Median	All	1.000	0.487	.045	2	view →
SCLC	OS	Median	All	1.000	0.612	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

TRPS1–LIHC (OS)

Open the LIHC breakdown →