TRPM8

Across TCGA patient cohorts, TRPM8 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,140 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TRPM8-associated GO terms across cancer lineages are Negative regulation of cell cycle G1/S phase transition, Endoplasmic reticulum to Golgi vesicle-mediated transport, and Glycosylation. Each is linked with TRPM8 in more than 14 cancer types. Because this analysis shows association rather than direction, both TRPM8-to-partner and partner-to-TRPM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle G1/S phase transition grouped by TRPM8-low versus TRPM8-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM8→partner) and Y-score (partner→TRPM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of cell cycle G1/S phase transition →	+0.046	+0.104	<.001	<.001	3	15
STAD	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.064	+0.106	<.001	<.001	3	14
STAD	Glycosylation →	+0.050	+0.140	<.001	<.001	3	14
STAD	Tissue regeneration →	+0.049	+0.104	<.001	<.001	3	14
STAD	Nuclear membrane reassembly →	+0.070	+0.141	<.001	<.001	3	14
STAD	Monosaccharide metabolic process →	+0.056	+0.103	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,140 associations by consensus.

Negative regulation of cell cycle G1/S phase transition by TRPM8 expression — STAD

Explore this box plot interactively →