TRPM8

Across TCGA patient cohorts, TRPM8 mutation is significantly associated with the RNA expression of many other genes, with 6,021 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPM8-associated genes across cancer lineages are NARF, MICU1, and RNA5SP412. Each is linked with TRPM8 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRPM8-to-partner and partner-to-TRPM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NARF grouped by TRPM8-low versus TRPM8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM8→partner) and Y-score (partner→TRPM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NARF →	+0.399	+1.555	<.001	<.001	3	4
COAD	MICU1 →	+0.386	+3.598	<.001	.001	3	4
UCEC	RNA5SP412 →	+0.327	+1.580	.001	<.001	3	4
SKCM	NIPAL2 →	-0.606	-1.359	.003	.008	3	3
SKCM	C1orf198 →	+0.469	+1.756	.003	.003	3	3
UCEC	ECHS1 →	+0.312	+1.565	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,021 associations by consensus.

NARF by TRPM8 expression — UCEC

Explore this box plot interactively →