TRPM8

Across TCGA patient cohorts, TRPM8 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPM8-associated genes across cancer lineages are Stathmin, TSC1, and ATM. Each is linked with TRPM8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPM8-to-partner and partner-to-TRPM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by TRPM8-low versus TRPM8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM8→partner) and Y-score (partner→TRPM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Stathmin →	+0.219	+2.708	<.001	.003	3	3
COAD	TSC1 →	-0.415	-2.691	<.001	.006	3	3
COAD	ATM →	-0.628	-3.169	<.001	.017	3	3
UCEC	eIF4E →	+0.175	+1.632	.003	<.001	3	2
COAD	INPP4B →	-0.533	-3.798	<.001	<.001	3	2
COAD	mTOR_pS2448 →	-0.234	-3.309	.001	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Stathmin by TRPM8 expression — COAD

Explore this box plot interactively →