TRPM8

Across TCGA cell cohorts, TRPM8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,770 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TRPM8-associated GO terms across cancer lineages are Protein localization to cilium, Ribonucleoside diphosphate catabolic process, and Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration. Each is linked with TRPM8 in more than 7 cancer types. Because this analysis shows association rather than direction, both TRPM8-to-partner and partner-to-TRPM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to cilium grouped by TRPM8-low versus TRPM8-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM8→partner) and Y-score (partner→TRPM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Protein localization to cilium →	+0.038	+1.798	.008	.004	3	7
SKIN	Ribonucleoside diphosphate catabolic process →	+0.125	+2.245	<.001	<.001	3	7
LIVER	Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration →	+0.131	+1.515	<.001	<.001	3	6
BREAST	Regulation of early endosome to late endosome transport →	+0.102	+0.411	.004	.003	1	8
SKIN	ADP metabolic process →	+0.099	+2.059	.001	.001	3	6
LUNG_NSCLC_LUAD	Nucleus organization →	+0.058	+0.420	.001	.002	1	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,770 associations by consensus.

Protein localization to cilium by TRPM8 expression — SKIN

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