TRPM8

Across TCGA cell cohorts, TRPM8 mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM8-associated genes across cancer lineages are OR10Q1, HMHB1, and OR9A2. Each is linked with TRPM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPM8-to-partner and partner-to-TRPM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10Q1 grouped by TRPM8-low versus TRPM8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM8→partner) and Y-score (partner→TRPM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10Q1 →	+0.118	+2.920	<.001	.001	3	2
BLOOD_Leukemia	HMHB1 →	+1.822	+3.442	.007	.005	3	2
SKIN	OR9A2 →	+0.272	+3.876	<.001	.003	3	2
BLOOD_Myeloma	ADAM7 →	+0.204	+4.285	.003	.003	3	1
URINARY_TRACT	TAS2R41 →	+0.019	+3.584	<.001	.005	3	1
LUNG_SCLC	ELSPBP1 →	+0.387	+3.898	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

OR10Q1 by TRPM8 expression — LARGE_INTESTINE

Explore this box plot interactively →