TRPM7

Across TCGA cell cohorts, TRPM7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,273 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRPM7-associated GO terms across cancer lineages are Intracellular magnesium ion homeostasis, Ubiquitin-dependent protein catabolic process via the N-end rule pathway, and Establishment of protein localization to vacuole. Each is linked with TRPM7 in more than 18 cancer types. Because this analysis shows association rather than direction, both TRPM7-to-partner and partner-to-TRPM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular magnesium ion homeostasis grouped by TRPM7-low versus TRPM7-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM7→partner) and Y-score (partner→TRPM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Intracellular magnesium ion homeostasis →	+0.161	+0.845	<.001	<.001	3	19
LUNG_SCLC	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.116	+0.621	<.001	<.001	3	15
LARGE_INTESTINE	Establishment of protein localization to vacuole →	+0.069	+0.748	<.001	<.001	3	14
LARGE_INTESTINE	Microtubule nucleation →	+0.101	+0.590	<.001	<.001	3	13
SKIN	Circadian sleep/wake cycle →	+0.178	+0.953	<.001	<.001	3	13
BLOOD_Myeloma	Regulation of maintenance of sister chromatid cohesion →	+0.105	+0.843	<.001	.004	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,273 associations by consensus.

Intracellular magnesium ion homeostasis by TRPM7 expression — LIVER

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