TRPM6

Across TCGA patient cohorts, TRPM6 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,447 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TRPM6-associated proteins across cancer lineages are SYNJ1, ZRANB2_S188, and PLCG2. Each is linked with TRPM6 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPM6-to-partner and partner-to-TRPM6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TRPM6 versus SYNJ1 in GBM, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM6→partner) and Y-score (partner→TRPM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYNJ1 →	+0.512	+0.669	<.001	<.001	3	4
BRCA	ZRANB2_S188 →	-0.681	-0.350	<.001	.001	3	4
BRCA	PLCG2 →	+0.444	+0.315	<.001	<.001	3	4
PDAC	RASGRP2 →	+0.429	+0.310	<.001	<.001	3	4
GBM	SEMA4D →	+0.506	+0.772	<.001	<.001	3	4
LUAD	CHL1 →	+0.500	+0.412	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,447 associations by consensus.

TRPM6 vs SYNJ1 — GBM

Explore this scatter interactively →