TRPM6

Across TCGA patient cohorts, TRPM6 mutation is significantly associated with the total protein of many other genes, with 108 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPM6-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-E2, and Rictor. Each is linked with TRPM6 in more than 5 cancer types. Because this analysis shows association rather than direction, both TRPM6-to-partner and partner-to-TRPM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TRPM6-low versus TRPM6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM6→partner) and Y-score (partner→TRPM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.374	+3.476	<.001	.002	3	6
COAD	Cyclin-E2 →	+0.169	+3.321	.049	.009	3	5
UCEC	Rictor →	-0.335	-1.142	.023	.048	3	4
UCEC	ATM →	-0.541	-1.624	<.001	<.001	3	4
UCEC	Caveolin-1 →	-0.482	-2.415	.010	.002	3	4
STAD	eEF2 →	+0.503	+3.169	<.001	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

Caspase-7-cleavedD198 by TRPM6 expression — COAD

Explore this box plot interactively →