TRPM6

Across TCGA cell cohorts, TRPM6 mutation is significantly associated with the RNA expression of many other genes, with 760 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM6-associated genes across cancer lineages are PTH2, RIT2, and PRAMEF9. Each is linked with TRPM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPM6-to-partner and partner-to-TRPM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH2 grouped by TRPM6-low versus TRPM6-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM6→partner) and Y-score (partner→TRPM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PTH2 →	+0.093	+4.807	<.001	.006	3	2
BLOOD_Myeloma	RIT2 →	+0.040	+4.807	<.001	.006	3	2
URINARY_TRACT	PRAMEF9 →	+0.010	+4.087	<.001	.009	3	2
SKIN	C11orf86 →	+0.071	+2.450	<.001	.007	3	2
CNS	SLC17A2 →	+0.016	+3.566	<.001	.003	3	2
CNS	NLRP13 →	+0.008	+3.145	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 760 associations by consensus.

PTH2 by TRPM6 expression — BLOOD_Myeloma

Explore this box plot interactively →