TRPM5

Across TCGA pan-cancer cohorts, TRPM5 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TRPM5 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TRPM5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRPM5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

COAD, OV, and KIRP are the cancer types where TRPM5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.331	0.761	<.001	22	view →
OV	DFS	Median	II,III,IV	0.174	0.541	.009	18	view →
KIRP	DFS	Median	All	0.178	0.829	<.001	15	view →
ESCA	OS	Median	II,III,IV	0.248	0.686	.019	9	view →
LUAD	OS	Median	All	0.357	0.701	.005	9	view →
UCEC	DFS	Median	II,III,IV	0.928	0.439	.030	6	view →
GBM	DFS	Median	All	1.000	0.193	.047	3	view →
SARC	DFS	Median	All	0.179	0.594	.031	3	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
HNSC	DFS	Median	All	1.000	0.316	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TRPM5–COAD (DFS)

Open the COAD breakdown →