TRPM2

Across TCGA pan-cancer cohorts, TRPM2 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated TRPM2 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRPM2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TRPM2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, OV, and LUAD are the cancer types where TRPM2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.964	0.823	.005	30	view →
OV	OS	Median	IV	0.022	0.760	<.001	12	view →
LUAD	OS	Median	II,III,IV	0.276	0.754	.003	12	view →
HNSC	OS	Median	II,III,IV	0.464	0.746	.013	10	view →
GBM	OS	Median	All	0.788	0.296	.019	8	view →
BLCA	OS	Median	III,IV	0.141	0.581	.011	6	view →
COAD	DFS	Median	III,IV	0.858	0.380	.028	4	view →
PAAD	DFS	Median	All	0.152	0.508	.042	3	view →
READ	OS	Median	III,IV	0.328	0.751	.003	3	view →
SKCM	OS	Median	II,III,IV	0.934	0.815	.016	2	view →
LUSC	DFS	Median	All	0.521	0.753	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

TRPM2–UCEC (DFS)

Open the UCEC breakdown →