TRPM2

Across TCGA cell cohorts, TRPM2 mutation is significantly associated with the RNA expression of many other genes, with 1,423 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM2-associated genes across cancer lineages are C10orf53, PHF5A, and DHRS13. Each is linked with TRPM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPM2-to-partner and partner-to-TRPM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by TRPM2-low versus TRPM2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM2→partner) and Y-score (partner→TRPM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C10orf53 →	+0.020	+5.357	<.001	.003	3	3
LARGE_INTESTINE	PHF5A →	+0.536	+2.743	<.001	.001	3	3
LARGE_INTESTINE	DHRS13 →	+0.705	+3.169	.006	.009	3	3
LARGE_INTESTINE	CYB5D1 →	+0.788	+3.234	.004	.004	3	3
LARGE_INTESTINE	C22orf46 →	+0.880	+3.169	.001	.006	3	3
BREAST	OR10K2 →	+0.038	+4.196	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,423 associations by consensus.

C10orf53 by TRPM2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →