TRPM2

Across TCGA cell cohorts, TRPM2 mutation is significantly associated with the mutation status of many other genes, with 5,161 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM2-associated genes across cancer lineages are ACAN, EYS, and TIAM2. Each is linked with TRPM2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TRPM2-to-partner and partner-to-TRPM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACAN grouped by TRPM2-low versus TRPM2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM2→partner) and Y-score (partner→TRPM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ACAN →	+3.608	+3.906	.004	.004	1	6
LUNG_NSCLC_LUAD	EYS →	+2.604	+2.604	.001	.001	1	5
LUNG_SCLC	TIAM2 →	+3.345	+2.977	<.001	<.001	1	5
BONE	LRRK2 →	+5.000	+4.437	.007	.007	1	4
OESOPHAGUS	FREM2 →	+3.672	+4.307	.004	.004	1	4
OESOPHAGUS	SLC12A1 →	+3.672	+4.307	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,161 associations by consensus.

ACAN by TRPM2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →