TRPM1

Across TCGA patient cohorts, TRPM1 mutation is significantly associated with the RNA expression of many other genes, with 5,819 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPM1-associated genes across cancer lineages are WDHD1, SUMO2P12, and PSMC3IP. Each is linked with TRPM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPM1-to-partner and partner-to-TRPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDHD1 grouped by TRPM1-low versus TRPM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM1→partner) and Y-score (partner→TRPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDHD1 →	+0.515	+1.483	<.001	<.001	3	5
HNSC	SUMO2P12 →	+0.221	+4.718	<.001	<.001	3	4
UCEC	PSMC3IP →	+0.659	+1.629	<.001	<.001	3	4
COAD	SKA1 →	+0.647	+2.920	<.001	.001	3	4
COAD	ZWILCH →	+0.486	+3.595	.007	.001	3	4
UCEC	CENPU →	+0.491	+1.415	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,819 associations by consensus.

WDHD1 by TRPM1 expression — UCEC

Explore this box plot interactively →