TRPM1

Across TCGA patient cohorts, TRPM1 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPM1-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and ASNS. Each is linked with TRPM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPM1-to-partner and partner-to-TRPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TRPM1-low versus TRPM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM1→partner) and Y-score (partner→TRPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.491	+1.434	.001	.005	3	5
LUAD	FoxM1 →	+0.344	+2.820	.010	.035	3	3
STAD	ASNS →	+0.415	+3.169	.046	.018	3	3
COAD	PKC-b-II_pS660 →	-0.394	-3.000	.008	.034	3	3
COAD	4E-BP1_pT70 →	+0.102	+2.593	.041	.006	3	3
UCEC	GAPDH →	+0.330	+1.925	.021	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Caspase-7-cleavedD198 by TRPM1 expression — UCEC

Explore this box plot interactively →