TRPM1

Across TCGA cell cohorts, TRPM1 mutation is significantly associated with the RNA expression of many other genes, with 261 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM1-associated genes across cancer lineages are ZAN, MRGPRD, and GFPT2. Each is linked with TRPM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPM1-to-partner and partner-to-TRPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by TRPM1-low versus TRPM1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM1→partner) and Y-score (partner→TRPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZAN →	+0.006	+5.000	<.001	.006	3	2
LUNG_NSCLC_LUAD	MRGPRD →	+0.056	+2.432	<.001	.009	3	2
LARGE_INTESTINE	GFPT2 →	+0.813	+3.169	.009	.009	3	2
LARGE_INTESTINE	RTP2 →	+0.008	+2.632	<.001	<.001	3	2
BLOOD_Leukemia	CMSS1 →	+0.501	+3.548	.002	.001	3	2
BLOOD_Myeloma	OR2T35 →	+0.086	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 261 associations by consensus.

ZAN by TRPM1 expression — PANCREAS

Explore this box plot interactively →