TRPC7

Across TCGA pan-cancer cohorts, TRPC7 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TRPC7 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TRPC7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRPC7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

KIRC, THYM, and KIRP are the cancer types where TRPC7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.054	0.806	<.001	48	view →
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
KIRP	OS	Median	All	0.135	0.703	.002	12	view →
UCEC	DFS	Median	All	0.920	0.619	.008	10	view →
BLCA	DFS	Median	III,IV	1.000	0.271	.024	9	view →
OV	OS	Median	IV	0.170	0.758	.044	6	view →
STAD	DFS	Median	All	0.838	0.385	.023	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SCLC	DFS	Median	All	1.000	0.272	.047	2	view →
SKCM	OS	Median	II,III,IV	1.000	0.707	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TRPC7–KIRC (OS)

Open the KIRC breakdown →