TRPC7

Across TCGA patient cohorts, TRPC7 mutation is significantly associated with the RNA expression of many other genes, with 3,460 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPC7-associated genes across cancer lineages are ZWINT, UBE2M, and POLE2. Each is linked with TRPC7 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPC7-to-partner and partner-to-TRPC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by TRPC7-low versus TRPC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC7→partner) and Y-score (partner→TRPC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.542	+1.387	<.001	.001	3	4
SKCM	UBE2M →	+0.277	+1.260	<.001	.006	2	5
UCEC	POLE2 →	+0.419	+2.413	<.001	<.001	3	4
UCEC	SDHB →	+0.267	+1.885	.005	.001	3	4
COAD	RAD51C →	+0.458	+3.730	<.001	<.001	3	4
UCEC	CDT1 →	+0.582	+1.919	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,460 associations by consensus.

ZWINT by TRPC7 expression — UCEC

Explore this box plot interactively →