TRPC7

Across TCGA cell cohorts, TRPC7 RNA expression is significantly associated with the go_rna of many other GO terms, with 398 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible TRPC7-associated GO terms across cancer lineages are Regulation of ferroptosis, Regulation of nucleotide metabolic process, and B cell apoptotic process. Each is linked with TRPC7 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRPC7-to-partner and partner-to-TRPC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of ferroptosis grouped by TRPC7-low versus TRPC7-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC7→partner) and Y-score (partner→TRPC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of ferroptosis →	+0.077	+0.025	.002	.005	3	3
SOFT_TISSUE	Regulation of nucleotide metabolic process →	+0.054	+0.046	.001	.007	3	3
KIDNEY	B cell apoptotic process →	+0.163	+0.451	.008	.005	2	4
OVARY	Positive regulation of vascular endothelial growth factor production →	+0.107	+0.131	.007	.006	3	3
KIDNEY	Sodium-dependent phosphate transport →	+1.367	+0.393	<.001	<.001	3	3
BLOOD_Lymphoma	Regulation of striated muscle cell apoptotic process →	+0.082	+0.046	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 398 associations by consensus.

Regulation of ferroptosis by TRPC7 expression — SOFT_TISSUE

Explore this box plot interactively →