TRPC7

Across TCGA cell cohorts, TRPC7 mutation is significantly associated with the RNA expression of many other genes, with 919 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPC7-associated genes across cancer lineages are SLC66A2, ACER1, and LRRC8B. Each is linked with TRPC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPC7-to-partner and partner-to-TRPC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC66A2 grouped by TRPC7-low versus TRPC7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC7→partner) and Y-score (partner→TRPC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC66A2 →	+0.923	+3.321	<.001	.003	3	2
LARGE_INTESTINE	ACER1 →	+0.066	+2.501	<.001	<.001	3	2
LARGE_INTESTINE	LRRC8B →	+0.809	+3.829	<.001	<.001	3	2
LARGE_INTESTINE	MBP →	+0.918	+2.628	.002	.002	3	2
LARGE_INTESTINE	PIM3 →	+0.614	+3.169	<.001	.006	3	2
LARGE_INTESTINE	TIMM21 →	+0.701	+2.628	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 919 associations by consensus.

SLC66A2 by TRPC7 expression — LARGE_INTESTINE

Explore this box plot interactively →