TRPC6

Across TCGA patient cohorts, TRPC6 protein abundance is significantly associated with the RNA expression of many other genes, with 2,620 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TRPC6-associated genes across cancer lineages are GINS3, TRIM59, and SNHG14. Each is linked with TRPC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPC6-to-partner and partner-to-TRPC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TRPC6 versus GINS3 in LUAD, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC6→partner) and Y-score (partner→TRPC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GINS3 →	-0.693	-0.675	<.001	.001	3	2
LSCC	TRIM59 →	-0.883	-0.538	.001	.001	3	2
LUAD	SNHG14 →	+0.976	+0.564	<.001	.001	3	2
UCEC	RNU6-213P →	-2.403	-1.756	<.001	.009	2	2
LUAD	STARD3NL →	-0.410	-0.537	.009	.005	3	1
LUAD	OAZ1 →	-0.326	-0.559	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,620 associations by consensus.

TRPC6 vs GINS3 — LUAD

Explore this scatter interactively →