TRPC6

Across TCGA patient cohorts, TRPC6 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPC6-associated genes across cancer lineages are Cyclin-E2, p90 RSK_pT359_S363, and Caspase-7-cleavedD198. Each is linked with TRPC6 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPC6-to-partner and partner-to-TRPC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by TRPC6-low versus TRPC6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC6→partner) and Y-score (partner→TRPC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-E2 →	+0.213	+1.891	<.001	.030	3	5
LUAD	p90 RSK_pT359_S363 →	-0.231	-3.000	.001	.034	3	4
COAD	Caspase-7-cleavedD198 →	+1.733	+2.824	<.001	.034	3	3
UCEC	eIF4G →	+0.326	+2.807	.002	.003	3	3
UCEC	JNK_pT183_Y185 →	-0.189	-2.807	.001	.002	3	3
UCEC	CDK1 →	+0.108	+1.750	.039	.049	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Cyclin-E2 by TRPC6 expression — LUAD

Explore this box plot interactively →