TRPC6

Across TCGA cell cohorts, TRPC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 858 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TRPC6-associated GO terms across cancer lineages are Intracellular mRNA localization, Regulation of translation in response to endoplasmic reticulum stress, and Branching involved in blood vessel morphogenesis. Each is linked with TRPC6 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPC6-to-partner and partner-to-TRPC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular mRNA localization grouped by TRPC6-low versus TRPC6-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC6→partner) and Y-score (partner→TRPC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Intracellular mRNA localization →	+0.087	+0.067	<.001	.003	3	5
LUNG_NSCLC_LUAD	Regulation of translation in response to endoplasmic reticulum stress →	+0.060	+0.515	.002	.008	3	4
SKIN	Branching involved in blood vessel morphogenesis →	+0.170	+0.068	.001	.005	3	4
URINARY_TRACT	Regulation of double-strand break repair via homologous recombination →	+0.043	+0.045	.001	<.001	3	4
LUNG_NSCLC_LUAD	Viral process →	+0.032	+0.505	.002	.009	3	3
LUNG_NSCLC_LUAD	Response to misfolded protein →	+0.084	+0.566	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 858 associations by consensus.

Intracellular mRNA localization by TRPC6 expression — CNS

Explore this box plot interactively →