TRPC6

Across TCGA cell cohorts, TRPC6 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPC6-associated genes across cancer lineages are NEU2, ALKBH7, and SDHAF4. Each is linked with TRPC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPC6-to-partner and partner-to-TRPC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEU2 grouped by TRPC6-low versus TRPC6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC6→partner) and Y-score (partner→TRPC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NEU2 →	+0.018	+2.054	<.001	.008	3	1
LARGE_INTESTINE	ALKBH7 →	+0.411	+3.064	.007	.009	3	1
LARGE_INTESTINE	SDHAF4 →	+0.682	+3.502	<.001	.001	3	1
LARGE_INTESTINE	WBP2NL →	+0.435	+3.169	<.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.103	+2.202	<.001	.006	3	1
LARGE_INTESTINE	TECRL →	+0.008	+2.977	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

NEU2 by TRPC6 expression — LARGE_INTESTINE

Explore this box plot interactively →