TRPC5

Across TCGA pan-cancer cohorts, TRPC5 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated TRPC5 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TRPC5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRPC5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

SCLC, UCEC, and UVM are the cancer types where TRPC5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.082	0.648	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.933	0.432	.011	26	view →
UVM	OS	Median	II,III,IV	0.218	0.718	.006	24	view →
ESCA	DFS	Median	III,IV	0.080	0.442	<.001	18	view →
BLCA	DFS	Median	All	0.854	0.326	.021	14	view →
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
SKCM	DFS	Median	II,III,IV	0.863	0.656	.021	9	view →
CHOL	DFS	Median	All	0.037	0.486	.001	6	view →
LIHC	DFS	Median	All	0.096	0.526	.023	6	view →
CESC	DFS	Median	All	0.454	0.745	.026	4	view →
PRAD	DFS	Median	All	0.548	0.935	.038	2	view →
LUAD	DFS	Median	All	0.742	0.314	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

TRPC5–SCLC (OS)

Open the SCLC breakdown →